Apoe4 – the Ancestral allele

APOE4 (A4) carriers, especially homozygotes (carry 2 copies of the APOE4 allele, A4/4s) are considered to have a genetic predisposition to a shortened life-span, cardiovascular disease, and most notoriously, to Alzheimer’s disease (up to 12x the risk). Because of this, A4 has been dubbed the Alzheimer’s gene, with some going as far as calling it…

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